منابع مشابه
Cell cycle and cancer.
Cancer is frequently considered to be a disease of the cell cycle. As such, it is not surprising that the deregulation of the cell cycle is one of the most frequent alterations during tumor development. Cell cycle progression is a highlyordered and tightly-regulated process that involves multiple checkpoints that assess extracellular growth signals, cell size, and DNA integrity. Cyclin-dependen...
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Objective(s):Berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor properties in some in vitro systems. But the effect of berberine on breast cancer has not yet been completely studied. In this study, we evaluated anticancer properties of berberine in comparison to doxorubicin. Materials and Methods: The antiproliferative effects of berberine and doxorubicin alone and in ...
متن کاملQuercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin
Objective(s):The colorectal cancer stem cells (CSCs) with the CD133+ phenotype are a rare fraction of cancer cells with the ability of self-renewal, unlimited proliferation and resistance to treatment. Quercetin has anticancer effects with the advantage of exhibiting low side effects. Therefore, we evaluated the anticancer effects of quercetin and doxorubicin (Dox) in HT29 cancer cells and its ...
متن کاملCancer and the cell cycle.
The purpose of this short review is to provide an overview of mammalian somatic cell cycle events and their controls. Cell cycle-related studies have been under way for only 5% of this millennium, yet since then nearly 20,000 references have appeared. This vast literature cannot be detailed here, nor can fundamental information obtained with other organisms such as yeast and Xenopus, or topics ...
متن کاملCell cycle control and cancer
Cancer is a multifaceted disease, but a common feature of most tumours is that they harbour one or more genetic mutations that allow them to proliferate outside their normal growth restraints. Proliferation is normally restrained through control of the cell division cycle, which in turn, is regulated by the Cdk family of serine/threonine kinases and their regulatory partners the cyclins. Here, ...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2003
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2003.36.1.060